Title of article :
Novel oxime and oxime ether derivatives of 12,14-dichlorodehydroabietic acid: Design, synthesis, and BK channel-opening activity
Author/Authors :
Yong-Mei Cui، نويسنده , , Eriko Yasutomi، نويسنده , , Yuko Otani، نويسنده , , Takashi Yoshinaga، نويسنده , , Katsutoshi Ido، نويسنده , , Kohei Sawada، نويسنده , , Masatoshi Kawahata، نويسنده , , Kentaro Yamaguchi، نويسنده , , Tomohiko Ohwada، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Oxime ether derivatives of the benzylic ketone of 12,14-dichlorodehydroabietic acid (diCl-DHAA, 4b) were synthesised, and their BK channel-opening activity was evaluated in an assay system of CHO-K1 cells expressing hBKα channels. Oxime ether structure on the B ring of diCl-DHAA significantly increased the BK channel-opening activity.
Keywords :
BK channels , Openers , 14-Dichlorodehydroabietic acid , oxime , oxime ether , 12
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
