Title of article
Chroman-3-amides as potent Rho kinase inhibitors
Author/Authors
Yen-Ting Chen، نويسنده , , Thomas D. Bannister، نويسنده , , Amiee Weiser، نويسنده , , Evelyn Griffin، نويسنده , , Li Lin، نويسنده , , Claudia Ruiz، نويسنده , , Michael D. Cameron، نويسنده , , Stephan Schürer، نويسنده , , Derek Duckett، نويسنده , , Thomas Schroter، نويسنده , , Philip LoGrasso، نويسنده , , Yangbo Feng، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
6406
To page
6409
Abstract
Inhibition of Rho kinase (ROCK) is an attractive strategy for the treatment of diseases such as hypertension, glaucoma, and cancer. Here we report chroman-3-amides as highly potent ROCK inhibitors with sufficient kinase selectivity, excellent cell activity, good microsomal stability, and desirable pharmacokinetic properties for study as potential therapeutic agents.
Keywords
rock , ROCK-II , Glaucoma , kinase , Chromans , Rho kinase
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800246
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