• Title of article

    Identification of small molecule agonists of the motilin receptor

  • Author/Authors

    Tom D. Heightman، نويسنده , , Elizabeth Conway، نويسنده , , David F. Corbett، نويسنده , , Gregor J. Macdonald، نويسنده , , Geoffrey Stemp، نويسنده , , Susan M. Westaway، نويسنده , , Paolo Celestini، نويسنده , , Stefania Gagliardi، نويسنده , , Mauro Riccaboni، نويسنده , , Silvano Ronzoni، نويسنده , , Kalindi Vaidya، نويسنده , , Sharon Butler، نويسنده , , Fiona McKay، نويسنده , , Alison Muir، نويسنده , , Ben Powney، نويسنده , , Kim Winborn، نويسنده , , Alan Wise، نويسنده , , Emma M. Jarvie، نويسنده , , Gareth J. Sanger، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2008
  • Pages
    6
  • From page
    6423
  • To page
    6428
  • Abstract
    High-throughput screening resulted in the identification of a series of novel motilin receptor agonists with relatively low molecular weights. The series originated from an array of biphenyl derivatives designed to target 7-transmembrane (7-TM) receptors. Further investigation of the structure–activity relationship within the series resulted in the identification of compound (22) as a potent and selective agonist at the motilin receptor.
  • Keywords
    Motilin , agonist , receptor , GPCR
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2008
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    800250

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=800250