Title of article
Calmodulin inhibitory activity of the malbrancheamides and various analogs
Author/Authors
Kenneth A. Miller، نويسنده , , Mario Figueroa، نويسنده , , Meriah W.N. Valente، نويسنده , , Thomas J. Greshock، نويسنده , , Rachel Mata، نويسنده , , Robert M. Williams، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
6479
To page
6481
Abstract
The preparation and biological activity of various structural analogs of the malbrancheamides are disclosed. The impact of indole chlorination, C-12a relative stereochemistry, and bicyclo[2.2.2]diazaoctane core oxidation state on the ability of these analogs to inhibit calmodulin dependent phosphodiesterase (PDE1) was studied, and a number of potent compounds were identified.image
Keywords
Calmodulin inhibition , Prenylated indole alkaloid , Malbrancheamide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800263
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