Author/Authors :
Jennifer A. Harrison، نويسنده , , K. P. Ravindranathan Kartha، نويسنده , , W. Bruce Turnbull، نويسنده , , Shona L. Scheuerl، نويسنده , , James H. Naismith، نويسنده , , Sergio Schenkman، نويسنده , , Robert A. Field، نويسنده ,
Abstract :
NeuAc-α-2,3-Gal-β-O-PNP has been synthesised and its ability to act as a substrate for the hydrolase and transferase activities of Trypanosoma cruzi trans-sialidase have been investigated. The turn-over of this compound shows marked differences from the behaviour of NeuAc-MU. In addition, distinct differences in the action of T. cruzi trans-sialidase and Clostridium perfringens neuraminidase on NeuAc-α-2,3-Gal-β-O-PNP were apparent.
