Author/Authors :
William Pendergast، نويسنده , , Benjamin R. Yerxa، نويسنده , , James G. Douglass III، نويسنده , , Sammy R. Shaver، نويسنده , , Robert W. Dougherty، نويسنده , , Catherine C. Redick، نويسنده , , Ingrid F. Sims، نويسنده , , Janet L. Rideout، نويسنده ,
Abstract :
A series of dinucleoside 5-polyphosphates UpnU (n=2–7) was synthesized. Their relative potencies as agonists at the G-protein-coupled receptors P2Y1, P2Y2, P2Y4, and P2Y6 were determined by intracellular calcium measurements using fluorescent imaging techniques. The correlation of phosphate chain length to activities at these receptors is discussed.
