Author/Authors :
James McNulty، نويسنده , , Justin Mao، نويسنده , , Romelo Gibe، نويسنده , , Ruowei Mo، نويسنده , , Sonja Wolf، نويسنده , , George R. Pettit، نويسنده , , Delbert L. Herald، نويسنده , , Michael R. Boyd، نويسنده ,
Abstract :
Two deoxy-analogues of the anticancer/antiviral agent pancratistatin containing functionality complementary to the minimum structural pharmacophore were synthesized and subjected to anticancer screening. One of the analogues exhibited selective inhibition of certain tumor cell lines but was significantly less potent than the natural products. The minimum structural pharmacophore has now been refined from eight to three possible structures.
