Author/Authors :
Y. Kashiwada، نويسنده , , J. Chiyo، نويسنده , , Y. Ikeshiro، نويسنده , , T. Nagao، نويسنده , , H. Okabe، نويسنده , , L. M. Cosentino، نويسنده , , K. Fowke، نويسنده , , K. H. Lee، نويسنده ,
Abstract :
Four isomers of 3,28-di-O-(dimethylsuccinyl)-betulin were prepared and evaluated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cells. 3-O-(3′,3′-Dimethylsuccinyl)-28-O-(2″,2″-dimethylsuccinyl)-betulin (11) was the most potent anti-HIV compound with an EC50 value of 0.00087 μM and a TI value of 42,400.
