Author/Authors :
Gabriel Navarrete-V?zquez، نويسنده , , Roberto Cedillo-Rivera، نويسنده , , Alicia Hern?ndez-Campos، نويسنده , , Lilian Yépez-Mulia، نويسنده , , Francisco Hern?ndez-Luis، نويسنده , , Juan Valdez، نويسنده , , Ra?l Morales، نويسنده , , Rafael Cortés، نويسنده , , Manuel Hernandez، نويسنده , , Rafael Castillo، نويسنده ,
Abstract :
2-(Trifluoromethyl)benzimidazole derivatives substituted at the 1-, 5-, and 6-positions have been synthesized and in vitro tested against the protozoa Giardia lamblia, Entamoeba histolytica, and the helminth Trichinella spiralis. Results indicate that all the compounds tested are more active as antiprotozoal agents than Albendazole and Metronidazole. One compound (20) was as active as Albendazole against T. spiralis. These compounds were also tested for their effect on tubulin polymerization and none inhibited tubulin polymerization.
