Author/Authors :
Akihiko Fujie، نويسنده , , Toshiro Iwamoto، نويسنده , , Bunji Sato، نويسنده , , Hideyuki Muramatsu، نويسنده , , Chiyoshi Kasahara، نويسنده , , Takahisa Furuta، نويسنده , , Yasuhiro Hori، نويسنده , , Motohiro Hino، نويسنده , , Seiji Hashimoto، نويسنده ,
Abstract :
The synthesis and biological properties of a novel water-soluble echinocandin-like lipopeptide, FR131535, are described. This compound displayed potent in vitro and in vivo antifungal activities. The hemolytic activity of FR901379 was reduced by replacing the acyl side chain. This compound showed good water-solubility, comparable to the natural product FR901379.
