Author/Authors :
Giovanni Sorba، نويسنده , , Massimo Bertinaria، نويسنده , , Antonella Di Stilo، نويسنده , , Alberto Gasco، نويسنده , , Maria M. Scaltrito، نويسنده , , Maria I. Brenciaglia، نويسنده , , Francesco Dubini، نويسنده ,
Abstract :
New anti-Helicobacter pylori (H. pylori) agents endowed with H2-antagonists properties were obtained by combining the lamtidine derived pharmacophoric group with the antibiotic calvatic acid. All the compounds were tested for their irreversible H2-antagonist properties and for their ability to inhibit 20 H. pylori strains, two of them metronidazole resistant. The most active derivative (compound 4) displayed antimicrobial activity similar to metronidazole.
