Title of article
Cytotoxic michael-type amine adducts of α-methylene lactones alantolactone and isoalantolactone
Author/Authors
Nicholas J. Lawrence، نويسنده , , Alan T. McGown، نويسنده , , Jane Nduka، نويسنده , , John A. Hadfield، نويسنده , , Robin G. Pritchard، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
429
To page
431
Abstract
Two series of cytotoxic (IC50, K562 cell line, 1–24 μM) α-aminomethyl substituted lactones 3 and 4 were prepared by stereoselective Michael-type addition of amines to alantolactone (1) and isoalantolactone (2). The lactones 1 and 2 and their amine adducts induce apoptosis and act as alkylating agents.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800364
Link To Document