Title of article
Synthesis and biological evaluation of novel amides of polyunsaturated fatty acids with dopamine
Author/Authors
Vladimir Bezuglov، نويسنده , , Mikhail Bobrov، نويسنده , , Natalia Gretskaya، نويسنده , , Alla Gonchar، نويسنده , , Galina Zinchenko، نويسنده , , Dominique Melck، نويسنده , , Tiziana Bisogno، نويسنده , , Vincenzo Di Marzo، نويسنده , , Dmitry Kuklev، نويسنده , , Jean Claude Rossi، نويسنده , , Jean-Pierre Vidal، نويسنده , , Thierry Durand، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
447
To page
449
Abstract
New amides of different fatty acids from the C18, C20, and C22 series with dopamine were synthesized. Pharmacological characterization in binding assays with rat brain membrane preparations and in the ‘tetrad’ of cannabinoid behavioral tests showed that, for these compounds, cannabinoid-like activity was dependent on the fatty acid moiety. Our data demonstrate that polyenoic fatty acid amides with dopamine comprise a new family of synthetic cannabimimetics.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800368
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