Author/Authors :
Vladimir Bezuglov، نويسنده , , Mikhail Bobrov، نويسنده , , Natalia Gretskaya، نويسنده , , Alla Gonchar، نويسنده , , Galina Zinchenko، نويسنده , , Dominique Melck، نويسنده , , Tiziana Bisogno، نويسنده , , Vincenzo Di Marzo، نويسنده , , Dmitry Kuklev، نويسنده , , Jean Claude Rossi، نويسنده , , Jean-Pierre Vidal، نويسنده , , Thierry Durand، نويسنده ,
Abstract :
New amides of different fatty acids from the C18, C20, and C22 series with dopamine were synthesized. Pharmacological characterization in binding assays with rat brain membrane preparations and in the ‘tetrad’ of cannabinoid behavioral tests showed that, for these compounds, cannabinoid-like activity was dependent on the fatty acid moiety. Our data demonstrate that polyenoic fatty acid amides with dopamine comprise a new family of synthetic cannabimimetics.
