Title of article
Synthesis and biological activity of novel macrocyclic antifungals: acylated conjugates of the ornithine moiety of the lipopeptidolactone FR901469
Author/Authors
J. DAVID BARRETT، نويسنده , , Akira Tanaka، نويسنده , , Keiko Harada، نويسنده , , Hidenori Ohki، نويسنده , , Etsuko Watabe، نويسنده , , Katsuyuki Maki، نويسنده , , Fumiaki Ikeda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
479
To page
482
Abstract
A series of acylated analogues of the novel macrocyclic lipopeptidolactone FR901469 has been prepared and evaluated for antifungal and hemolytic activity. Several analogues displayed markedly reduced hemolytic potential and comparable protective effects to the natural product in a mouse model of candidiasis.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800376
Link To Document