Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3′ group chirality

Structure–activity relationships are described for a series of succinyl hydroxamic acids 1a–o and their carboxylic acid analogues 2a–o as inhibitors of matrix metalloproteases MMP-3 and MMP-2. For this series (P1′=(CH2)3Ph, P2′=t-Bu) selectivity for the inhibition of MMP-2 was found to be strongly dependent on P3′.