Title of article
Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3′ group chirality
Author/Authors
M. Jonathan Fray، نويسنده , , M. Frank Burslem، نويسنده , , RogerP. Dickinson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
567
To page
570
Abstract
Structure–activity relationships are described for a series of succinyl hydroxamic acids 1a–o and their carboxylic acid analogues 2a–o as inhibitors of matrix metalloproteases MMP-3 and MMP-2. For this series (P1′=(CH2)3Ph, P2′=t-Bu) selectivity for the inhibition of MMP-2 was found to be strongly dependent on P3′.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
800397
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