Management of neurogenic orthostatic hypotension: an update

Summary Orthostatic hypotension (OH) is common in elderly people and in patients with disorders such as diabetes and Parkinsonʹs disease. Grading of the severity of OH and its effect on the patientʹs quality of life are important. The symptoms vary with orthostatic stress, and subtle symptoms such as tiredness and cognitive impairment should be recognised. Standard drug treatment for OH is effective but worsens supine hypertension, whereas pyridostigmine can improve OH slightly but significantly without worsening of supine hypertension. Because orthostatic stress varies from moment to moment and drug treatment is suboptimal, drug treatment of OH needs to be combined with non-pharmacological approaches, such as compression of venous capacitance beds, use of physical counter-manoeuvres, and intermittent water-bolus treatment.