Title of article :
Eight-year change in body mass index and subsequent risk of cardiovascular disease among healthy non-smoking men
Author/Authors :
Thomas S. Bowman، نويسنده , , Tobias Kurth، نويسنده , , Howard D. Sesso، نويسنده , , Joann E. Manson، نويسنده , , J. Michael Gaziano، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Pages :
6
From page :
436
To page :
441
Abstract :
Objective. To determine how change in BMI over 8 years is associated with risk of subsequent cardiovascular disease (CVD) among middle aged men. Methods. Prospective cohort study among 13,230 healthy men (aged 51.6 ± 8.7 years) in the Physiciansʹ Health Study. BMI was collected at baseline in 1982 and after 8 years, at which time follow-up began. Subsequent CVD events were collected and confirmed through March 31, 2005. Cox proportional hazards models evaluated BMI at 8 years and risk of CVD, 8-year change in BMI and risk of CVD, and whether change in BMI added prognostic information after the consideration of BMI at 8 years. Results. 1308 major CVD events occurred over 13.5 years. A higher BMI at year 8 was associated with an increased risk of CVD. Compared to a stable BMI (± 0.5 kg/m2), a 0.5–2.0 kg/m2 increase had a multivariable-adjusted RR of 1.00 (0.86–1.16). A ≥ 2.0 kg/m2 increase had a multivariable-adjusted RR of 1.39 (1.16–1.68), however further adjustment for BMI reduced the RR to 1.00 (0.81–1.23). A decrease in BMI had a multivariable RR of 1.23 (1.07–1.42) which was unaffected by adjustment for BMI at 8 years. Conclusion. A higher BMI and a rising BMI were both associated with an increased risk of CVD, however an increasing BMI did not add prognostic information once current BMI was considered. In contrast, a declining BMI was associated with an increased risk of CVD independent of current BMI.
Keywords :
body mass index , risk factors , Cardiovascular disease , prospective studies
Journal title :
Preventive Medicine
Serial Year :
2007
Journal title :
Preventive Medicine
Record number :
804716
Link To Document :
بازگشت