Effects of cardiac output on Doppler transmitral and transtricuspid flow velocity patterns in very low birth weight infants

We studied effects of cardiac output on Doppler transmitral and transtricuspid flow velocities in 24 appropriate for gestational age premature infants. We measured peak flow velocity of early diastole (peak E) and atrial contraction (peak A), ratio of peak flow velocity of early diastole to atrial contraction (peak E/A), total flow velocity-time integral, the first third filling fraction, peak filling rate normalized to stroke volume, and deceleration time (DT). Cardiac output was calculated as the product of the aortic flow velocity-time integral, aortic valve area, and heart rate. The cardiac output increased significantly with advancing gestational age and body weight (r = 0.78 and 0.86, P < 0.01, respectively). With increasing cardiac output, the transmitral as well as transtricuspid peak E, peak E/A, and total flow velocity-time integral increased significantly without any change in the peak filling rate normalized to stroke volume, peak A, and deceleration time. The transmitral as well as transtricuspid peak E did not correlate with the heart rate. Although these results do not establish whether changes in ventricular relaxation process or in cardiac output is responsible for the progressive increase in the peak E and peak E/A. Unchanged peak filling rate normalized to stroke volume of the left and right ventricles suggest that changes in cardiac output with maturity is, in fact, one of the important contributory factors. This evidence should be borne in mind in interpreting ventricular diastolic filling as an index of ventricular diastolic function in premature infants.