Immunogenetic analysis of Buergerʹs disease in India

In order to understand the role of HLA linked factors in determining susceptibility to Buergerʹs disease, we have studied 21 unrelated Asian Indian patients belonging to the North Indian states of Punjab, Haryana, Uttar Pradesh and Delhi, representing mainly a lower socioeconomic background. The data was compared with healthy controls belonging to the same ethnic group. The study revealed an over representation of HLA-B40 (60+61) (χ2=6.12; P<0.02) and DR2 (χ2=10.2; P<0.002). Amongst the patients no particular association or linkage disequilibrium with any of the five alleles of the MIC-A gene could be derived in the small sample size studied.