Author/Authors :
Antonio Abbate، نويسنده , , Celina Morales، نويسنده , , Maria De Falco، نويسنده , , Valentina Fedele، نويسنده , , Giuseppe G.L. Biondi-Zoccai، نويسنده , , Daniele Santini، نويسنده , , Jimena Palleiro، نويسنده , , Fortunata Vasaturo، نويسنده , , Susanna Scarpa، نويسنده , , Giovanna Liuzzo، نويسنده , , Anna Severino، نويسنده , , Feliciano Baldi، نويسنده , , Filippo Crea، نويسنده , , Luigi M. Biasucci، نويسنده , , George W. Vetrovec، نويسنده , , Ricardo J. Gelpi، نويسنده , , Alfonso Baldi، نويسنده ,
Abstract :
Apoptosis is a pathologic feature of cardiomyocytes in acute myocardial infarction (AMI) and heart failure. The temporal course of apoptosis in the peri-infarct area in the weeks following an AMI is still uncompletely defined. In order to study the time course of apoptosis after AMI, 16 rabbits underwent left coronary artery ligation and were sacrificed at 16, 26, 35, and 56 days after surgery. Increased apoptotic rate (AR) was observed at in the peri-infarct region than in remote myocardium (5.4% [2.5–9.6] vs 0.4% [0.1–0.9], respectively, P < 0.001) and than in sham-operated cases (0.01% [0–0.02], P < 0.001). A gradual decrease of AR in the peri-infarct region was observed over time with a 90% reduction at 8 weeks after coronary ligation.
Keywords :
ischemia , apoptosis , remodelling , animal model , electron microscopy
