Late stent thrombosis after transcoronary transplantation of granulocyte-colony stimulating factor-mobilized peripheral blood stem cells following primary percutaneous intervention for acute myocardial infarction

Transcoronary transplantation of autologous stem cells (ASC) can improve cardiac function after myocardial infarction. For ASC-propagation, granulocyte-colony stimulating factor (G-CSF) is widely used. However, a clinical long-term safety profile of combining G-CSF therapy and transcoronary ASC-transplantation does not exist. We report on three cases of late stent thrombosis in a cohort of 24 patients who had undergone intracoronary infusion of G-CSF-mobilized ASC after primary stenting for acute myocardial infarction.