Effect of l-arginine on circulating endothelial progenitor cells and VEGF after moderate physical training in mice

Alteration of levels and functional activities of circulating endothelial progenitor cells (EPCs) induced by risk factors for coronary heart disease (CHD) profoundly influence their role in the regeneration of tissue ischemia and angiogenesis. Among antioxidant nutrients in the prevention of CHD, l-arginine is particularly effective in enhancing the protection afforded by moderate physical exercise. Here, we aimed to evaluate the effects of l-arginine on EPC levels in C57BL/6J mice subjected to moderate physical exercise. Results showed that supplementation with l-arginine potentiates the effects of moderate physical exercise by increasing significantly EPCs (P < 0.001) and VEGF serum levels (P < 0.001). Our report highlights the beneficial effect of l-arginine in the modulation of EPC levels and VEGF secretion.