Author/Authors :
H. Gohlke، نويسنده , , T. Illig، نويسنده , , N. Klopp، نويسنده , , S. Wagenpfeil، نويسنده , , L. Konta، نويسنده , , S.M. Laws، نويسنده , , A. Kurz، نويسنده , , M. Riemenschneider، نويسنده ,
Abstract :
Several studies have reported conflicting results concerning the genetic association between Alzheimerʹs disease (AD) and the microsatellite marker D10S1423 on chromosome 10p12-14. In an ethnically homogeneous German population of 422 patients with AD and 254 cognitively healthy controls, the 238-bp allele of the D10S1423 marker showed a weak, but after correction for multiple testing no longer significant association with AD (p = 0.015, uncorrected; p = 0.11, corrected). These findings do not support the presence of a relevant susceptibility locus for AD on chromosome 10p12-14.
