Author/Authors :
Marianna Zana، نويسنده , , Anna Juh?sz، نويسنده , , ?gnes Riman?czy، نويسنده , , Annam?ria Bjelik، نويسنده , , Eszter Balt?s، نويسنده , , Imre Ocsovszki، نويسنده , , Krisztina Boda، نويسنده , , Botond Penke، نويسنده , , Attila Dobozy، نويسنده , , Lajos Kemeny، نويسنده , , Zolt?n Janka، نويسنده , , J?nos K?lm?n، نويسنده ,
Abstract :
In the present pilot investigation, the susceptibility of T-lymphocytes from Alzheimerʹs disease (AD) subjects (n = 22) and aged-matched, non-demented controls (CNT) (n = 12) was examined with ultraviolet (UV) B light-induced apoptosis in vitro. The basal apoptotic ratios were similar in both groups. However, the AD lymphocytes displayed significantly (p < 0.0001) lower apoptotic levels than those of the CNT lymphocytes at all of the applied UVB exposure doses (100, 200 and 300 mJ/cm2). These observations indicate that AD lymphocytes are more resistant than CNT lymphocytes to UVB irradiation.
Keywords :
T-lymphocytes , Ultraviolet B irradiation , flow cytometry , Alzheimer’s Disease , Apoptosis
