Author/Authors :
M. Riemenschneider، نويسنده , , A. Schoepfer-Wendels، نويسنده , , P. Friedrich، نويسنده , , L. Konta، نويسنده , , S.M. Laws، نويسنده , , J.C. Mueller، نويسنده , , A. Kurz، نويسنده , , H. F?rstl، نويسنده ,
Abstract :
Using a case-control sample we evaluated a possible involvement of the Vacuolar protein sorting 26 (VPS26) gene in the pathogenesis of AD. VPS26 located at 10q22.1 denotes a retromer subunit functionally involved in the cellular trafficking of Memapsin 2 (BACE). Genotyping of eight single nucleotide polymorphisms covering the complete VPS26 gene and haplotypic analysis revealed no association with AD. Thus, we conclude that VPS26 can be excluded as a major positional and functional candidate gene conferring risk to AD.
Keywords :
Genetic analysis , Alzheimer’s disease , association study , VPS26
