Author/Authors :
Leon Flicker، نويسنده , , Ralph N. Martins، نويسنده , , Jenny Thomas، نويسنده , , John Acres، نويسنده , , Kevin Taddei، نويسنده , , Samuel D. Vasikaran، نويسنده , , Paul Norman، نويسنده , , Konrad Jamrozik، نويسنده , , Osvaldo P. Almeida، نويسنده ,
Abstract :
Elevated plasma homocysteine (tHcy) is a risk factor for Alzheimerʹs disease (AD), and thus B vitamins may have a role in the prevention of AD. The objective of this study was to determine if tHcy lowering vitamins decrease the circulating levels of A-beta protein 1–40 (Aβ40). We randomized 299 older men to treatment with 2 mg of folate, plus 25 mg of B6 and 400 μg of B12, or placebo. After 2 years of treatment the mean (S.E.) increase of Aβ40 was 7.0 pg/ml (8.4) in the vitamin group (4.9%), and 26.8 pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of Aβ40 and have a role in the prevention of AD.
