Title of article :
Age-related slowing of memory retrieval: Contributions of perceptual speed and cerebral white matter integrity
Author/Authors :
Barbara Bucur، نويسنده , , David J. Madden، نويسنده , , Julia Spaniol، نويسنده , , James M. Provenzale، نويسنده , , Roberto Cabeza، نويسنده , , Leonard E. White، نويسنده , , Scott A. Huettel، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
10
From page :
1070
To page :
1079
Abstract :
Previous research suggests that, in reaction time (RT) measures of episodic memory retrieval, the unique effects of adult age are relatively small compared to the effects aging shares with more elementary abilities such as perceptual speed. Little is known, however, regarding the mechanisms of perceptual speed. We used diffusion tensor imaging (DTI) to test the hypothesis that white matter integrity, as indexed by fractional anisotropy (FA), serves as one mechanism of perceptual slowing in episodic memory retrieval. Results indicated that declines in FA in the pericallosal frontal region and in the genu of the corpus callosum, but not in other regions, mediated the relationship between perceptual speed and episodic retrieval RT. This relation held, though to a different degree, for both hits and correct rejections. These findings suggest that white matter integrity in prefrontal regions is one mechanism underlying the relation between individual differences in perceptual speed and episodic retrieval.
Keywords :
Episodic memory , Region of interest , Neuroimaging , aging , white matter , Memory retrieval , cognition , Fractional anisotropy
Journal title :
Neurobiology of Aging
Serial Year :
2008
Journal title :
Neurobiology of Aging
Record number :
821211
Link To Document :
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