Predicting in silico bioprocess additive and food additive undesirable outcomes due to utilising cytochrome P450 isoform metallomimics

Up to 2700 isoforms of cytochromes P450 bioconvert components of food bioprocessing. Nutragenomics define the biotransformation abilities of particular cytochromes P450 selected from 57 human isoforms in appropriate tissues such as the liver. Safety predictions solely in silico are unreliable using metallomimics of the Fe-containing enzymes.