Torsade de pointes occurring early during oral amiodarone treatment

Amiodarone is reported to have a low incidence of proarrhythmic effects. They generally occur during chronic treatment in association with increase in amiodarone dosage, electrolyte disorders, or concomitant therapy with class IA antiarrhythmic drugs. We describe a case of amiodarone-induced torsade de pointes early after initiation of low-dose oral therapy, in absence of other predisposing factors.