Known effects of levothyroxine and folic acid on serum homocysteine level

This refers to Dr. Ziaee et al.’s manuscript published in your valuable journal about serum homocysteine level entitled “Effects of folic acid plus levothyroxine on serum homocysteine level in hypothyroidism”. In this clinical trial study the efficacy of concomitant administration of folic acid and levothyroxine versus single levothyroxine prescription on serum homocysteine level was compared with hypothyroid patients. The authors concluded that “levothyroxine can decrease serum homocysteine level partly; still its combination with folic acid empowers the effect. Combination therapy declines serum homocysteine level more successfully (1).”