Author/Authors :
Panahi، Yunes نويسنده , , Ghanei، Mostafa نويسنده , , Ghabili، Kamyar نويسنده Physical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , , Ansarin، Khalil Ansarin نويسنده Tuberculosis and Lung Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran , , Aslanabadi، Saeid نويسنده Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz , , Poursaleh، Zohreh نويسنده Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran , , Eslam Jamal Golzari، Samad نويسنده Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz , , Etemadi، Jalal نويسنده Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences, Tabriz , , Khalili، Majid نويسنده Physical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences, Tabriz , , Mohajel Shoja، Mohammadali نويسنده Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz ,
Abstract :
Purpose: To review the acute and chronic pathological effects of sulfur mustard on the
genitourinary system and male fertility.
Materials and Methods: We searched PubMed and Google Scholar to find studies
related to the sulfur mustard-induced genitourinary effects and male infertility. Information
in the abstracts of non-English related papers as well as those in the proceedings of
congresses on sulfur mustard were reviewed as well.
Results: In acute phase after sulfur mustard exposure, evidences are in favor of microscopic
and macroscopic renal lesions, very low androgen levels, and impaired spermatogenesis.
Several years following sulfur mustard exposure, the long-term pathological
effects vary from the renal function impairment to the gonadal damage, in particular, the
spermatogenesis. Nevertheless, carcinogenic effect of sulfur mustard on the genitourinary
system as well as the prevalence of male infertility among sulfur mustard-exposed
veterans in the chronic post-exposure phase is still unclear.
Conclusion: Sulfur mustard causes both acute and chronic injuries to different parts of
the genitourinary system.
