Author/Authors :
Dorgalaleh ، A نويسنده Hematology Department Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran. , , Mahmoodi ، M نويسنده Pars pathobiology laboratory, Minoodasht, Golestan, Iran. , , Varmaghani ، B نويسنده Hematology Department Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran. , , Kiani node، F نويسنده Hematology Department Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran. , , Saeeidi Kia، O نويسنده Medical Laboratory Sciences Department Allied Medical School, Zahedan University of Medical Sciences, Zahedan, Iran. , , Alizadeh، SH نويسنده Dept. of Surgery, Valiasr Hospital, Arak University of Medical Sciences, Arak, Iran , , Tabibian ، Sh نويسنده Allied Medicl School, Departman of Hematology, Tehran University of Medical Science, Tehran, Iran , , Bamedi، T نويسنده Parasitology Department Allied Medical School, Zahedan University of Medical Sciences, Zahedan, Iran. , , Momeni ، M نويسنده Imam Ali hospital, Sistan and Baluchistan, Chahbahar, Iran. , , Abbasian، S نويسنده Hematology Department Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran. , , Kashani Khatib ، Z نويسنده Hematology Department Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran. ,
Abstract :
Abstract
Background
Thyroid hormones have a crucial role in metabolism and proliferation of blood cells. Thyroid dysfunction induces different effects on blood cells such as anemia, erythrocytosis leukopenia, thrombocytopenia, and in rare cases causes’ pancytopenia. It also alter RBC indices include MCV, MCH, MCHC and RDW. Thus this study attempted to evaluate effect of hypo & hyperthyroidism on blood cell count and RBC indices.
Materials and Methods
This study performed on 102 patients with hypothyroid (14.1 years), 84 with hyperthyroid (15.6 years) and 118 healthy individuals (15.2 years) as control group. Initially patients TSH level of patients was determined by ELISA method, and then according to TSH ranges (0.3-5.5µIU/mL) patients
were divided into two Hyperthyroidism (TSH < 0.3µIU/mL) and hypothyroidism (TSH > 5.5µIU/mL) groups. Then, complete blood count was measured by cell counter. Finally, obtained results were analyzed by SPSS software.
Results
Analyzes of obtained data revealed statistically significant difference between two groups of patients in RBC count, MCH, MCHC, RDW, HB and HCT(P-value < 0.05), but the difference was not significant for WBC and PLT counts and MCV (P-value > 0.05).
Conclusion
In case of patients with unknown hematological dysfunctions, must be evaluated for thyroid hormones.
