Bayesian interim analysis of lifetime data

In hypothesis testing involving censored lifetime data that are independently distributed according to an accelerated-failure-time model, it is often of interest to predict whether continuation of the experiment will significantly alter the inferences drawn at an interim point. Approaching the problem from a Bayesian viewpoint, we suggest a possible solution based on Laplace approximations to the posterior distribution of the parameters of interest and on Markov-chain Monte Carlo. We apply our results to Weibull data form a carcinogenesis experiment on mice.