Title of article
Confidence Bands for Low-Dose Risk Estimation with Quantal Response Data
Author/Authors
O.M.، Al-Saidy نويسنده , , W.W.، Piegorsch نويسنده , , R.W.، West نويسنده , , D.K.، Nitcheva نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
-1055
From page
1056
To page
0
Abstract
We study the use of simultaneous confidence bands for low-dose risk estimation with quantal response data, and derive methods for estimating simultaneous upper confidence limits on predicted extra risk under a multistage model. By inverting the upper bands on extra risk, we obtain simultaneous lower bounds on the benchmark dose (BMD). Monte Carlo evaluations explore characteristics of the simultaneous limits under this setting, and a suite of actual data sets are used to compare existing methods for placing lower limits on the BMD.
Keywords
Benchmark analysis , Benchmark dose , Carcinogenic risk assessment , Quantal data , Quantitative risk analysis , Simultaneous confidence bounds , Toxicology , Low-dose extrapolation , Multistage model
Journal title
BIOMETRICS (BIOMETRIC SOCIETY)
Serial Year
2003
Journal title
BIOMETRICS (BIOMETRIC SOCIETY)
Record number
84216
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