Abstract :
The purpose of this study was to determine the pharmacokinetic profile of marbofloxacin in
llamas following single IV, IM and SC administration of 5 mg/kg bw. To assess whether these
routes could be an option for the administration of marbofloxacin in this specie and estimate
efficacy predictors (PK/PD) from bibliographic MIC90 values. The principal pharmacokinetic
parameters were Vss = 0.72
±
0.22 L/kg, Cl = 0.09
±
0.03 L/kg h (for IV administration),
Cmax = 7.43
±
1.28 g/mL and 6.94
±
2.19 g/mL for IM and SC administration, respectively;
t1/2 = 9.16
±
1.08 h, 8.47
±
0.31 h and 6.26
±
0.87 h and MRT = 7.30
±
1.07 h, 8.21
±
1.57 h
and 8.27
±
0.96 h for IV, IM and SC administrations, respectively. The values obtained for the
pharmacokinetic parameters were not significantly different among routes of administration
except Cmax, Vz and t1/2 . The values obtained from the PK/PD indices were Cmax/MIC90
(12.4–32.3) and AUC0–24/MIC90 (105.7–178.52 h); taking into account these values, it was
concluded that a IM or SC dose of 5 mg/(kg day) of marbofloxacin would be adequate in
treating infections caused by susceptible bacteria with MIC < 0.44 g/mL.
