Author/Authors :
MIRFEIZI، ZAHRA نويسنده Assistant Professor of Rheumatology, Rheumatic disease research center (RDRC), Mashhad University of Medical Sciences, Mashhad, Iran. , , JOKAR، MOHAMMADHASSAN نويسنده Associate Professor of Rheumatology, Rheumatic disease research center (RDRC), Mashhad University of Medical Sciences, Mashhad, Iran. , , HASHEMZADEH، KAMILA نويسنده Assistant Professor of Research in Rheumatology, Rheumatic disease research center (RDRC), Mashhad University of Medical Sciences, Mashhad, Iran. , , MOHEBI، MAHMOOD نويسنده Internist, Rheumatic disease research center (RDRC), Mashhad University of Medical Sciences, Mashhad, Iran. , , JAVIDI، KAMBIZ نويسنده 5Pathologist, Pathology Department, Mashhad University of Medical Sciences, Mashhad, Iran. ,
Abstract :
Abstract
Macrophage Activation Syndrome (MAS) is an aggressive and potentially life threatening disease which can
occur in rheumatologic diseases, more in systemic juvenile idiopathic arthritis and less in adult onset Still’s
disease. We presented here a 22-yr-old female who was admitted with high fever for 3 weeks before admission.
According to physical and laboratory results and after ruling out infections and malignancies, she was diagnosed
with adult onset Still disease. Despite treatment initiation and improvement, she became dramatically ill one
week later and jaundice was created. In physical and laboratory data, high fever, pancytopenia and impaired liver
function tests and increased serum ferritin levels were found. Bone marrow aspiration and biopsy showed active
hemophagocytosis. She was diagnosed with Macrophage Activation Syndrome associated with adult onset Still’s
disease and managed with high-dose corticosteroids and cyclosporine. After this treatment she completely
recovered.
