Author/Authors :
Kianpour، Maryam نويسنده Nursing and Midwifery Care Research Centre, Department of Midwifery, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfaha , , Nematbakhsh، Mehdi نويسنده , , Ahmadi، Sayad Mehdi نويسنده Isfahan Fertility and Infertility Centre, Isfahan, Iran , , Jafarzadeh، Mehrangiz نويسنده Isfahan Fertility and Infertility Centre, Isfahan, Iran , , Hajjarian ، Masomeh نويسنده Isfahan Fertility and Infertility Centre, Isfahan, Iran , , Pezeshki، Zahra نويسنده , , Safari، Tahereh نويسنده , , Eshraghi-Jazi، Fatemeh نويسنده ,
Abstract :
Background: Endometriosis is known as one of the most common disease in women of
reproductive age. Due to important role of vascular endothelial growth factor (VEGF) in
neo-vascularization for the implantation of endometrial cell, and also presence of different
studies
reported
VEGF
level
in
the
serum
and
peritoneal
fluid
(PF)
in
endometriosis
patients,
this
study
was
designed
to
determine
the
serum
and
PF
levels
of
VEGF
in
endometriosis
patients, and to compare with normal subjects.
Materials and Methods: In this descriptive study, 179 women subjected to laparoscopy
for the evaluation of infertility or pelvic pain were allocated into the following two groups:
group I: different types of endometriosis patients (n=90) and group II: non-endometriosis
patients (n=89). The PF from pelvis and venous blood samples were obtained. The VEGF
concentration of the serum and PF were measured using enzyme immunoassay kit and were
compared using t test.
Results: The level of VEGF in serum was significantly less than that in PF in both groups
(p=0.00). However, endometriosis patients had significantly higher level of VEGF in
peritoneal fluid than non-endometriosis patients (p=0.043).
Conclusion: According to our findings, endometriosis is not associated with change in
the level of circulating VEGF.
