Title of article :
The Effects of ISM1 Medium on Embryo Quality and Outcomes of IVF/ICSI Cycles
Author/Authors :
Hassani، Fatemeh نويسنده , , Eftekhari-Yazdi، Poopak نويسنده Baghaban Eslaminejad, M.R. , Karimian، Leila نويسنده Department of Embryology at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , , Rezazadeh Valojerdi، Mojtaba نويسنده , , Movaghar، Bahar نويسنده Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , , Fazel Zarandi، Mohammad Hossein نويسنده Professor of Department of Industrial Engineering, Tehran, Iran , , Fouladi، Hamid Reza نويسنده Department of Embryology at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , , Shabani، Fatemeh نويسنده , , Johansson، Lars R. K. نويسنده ,
Issue Information :
فصلنامه با شماره پیاپی 26 سال 2013
Pages :
8
From page :
108
To page :
115
Abstract :
Background: The aim of this study is to investigate the effect of ISM1 culture medium on embryo development, quality and outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles. This study compares culture medium commonly used in the laboratory setting for oocyte recovery and embryo development with a medium from MediCult. We have assessed the effects of these media on embryo development and newborn characteristics. Materials and Methods: In this prospective randomized study, fertilized oocytes from patients were randomly assigned to culture in ISM1 (MediCult, cycles: n=293) or routine lab culture medium (G-1 v5; Vitrolife, cycles: n=290) according to the daily media schedule for oocyte retrieval. IVF or ICSI and embryo transfer were performed with either MediCult media or routine lab media. Embryo quality on days 2/3, cleavage, pregnancy and implantation rates, baby take home rate (BTHR), in addition to the weight and length of newborns were compared between groups. TM Results: There were similar cleavage rates for ISM1 (86%) vs. G-1 v5 (88%). We observed a significantly higher percentage of excellent embryos in ISM1 (42.7%) compared to G-1 TM TM v5 (39%, p < 0.05). Babies born after culture in ISM1 had both higher birth weight (3.03 kg) and length (48.8 cm) compared to G-1 v5 babies that had a birth weight of 2.66 kg and a length of 46.0 cm (p < 0.001 for both). TM Conclusion: This study suggests that ISM1 is a more effective culture medium in generating higher quality embryos, which may be reflected in the characteristics of babies at birth.
Journal title :
International Journal of Fertility and Sterility
Serial Year :
2013
Journal title :
International Journal of Fertility and Sterility
Record number :
883858
Link To Document :
بازگشت