Author/Authors :
Zhang، Changjun نويسنده The Reproductive Research Center, Renmin Hospital, Hubei university of Medicine, Shiyan, China , , Peng، Haiying نويسنده The Reproductive Research Center, Renmin Hospital, Hubei university of Medicine, Shiyan, China , , Hu، Yueyue نويسنده The Reproductive Research Center, Renmin Hospital, Hubei university of Medicine, Shiyan, China ,
Abstract :
A 24-year-old man was diagnosed with klinefelter’s syndrome (KS) and his wife was
found to have an inversion on chromosome 9-46, XX, inv (9) (p11q21)- because of infertility.
Intracytoplasmic sperm injection (ICSI) was performed for fertilization after fluorescence
in-situ hybridization (FISH) was used to analyze the aneuploidy rate of the X
and Y chromosomes of the ejaculated sperms of the patient, and 99 sperms were haploid
among 100 sperms that were to be analyzed. A twin pregnancy was achieved. The chromosomes
of the two fetuses were identified as 46, XY and 46, XY, inv (9)(p11q21) after a
prenatal diagnosis at 18 weeks gestation. Two healthy twins were born through caesarean
section at 32 weeks gestation because of premature rupture of membranes (PROM).
