Author/Authors :
OMIDVARI، SHAPOUR نويسنده , , Nasrolahi، Hamid نويسنده Department of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , , Kani، Amir Abbas نويسنده Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran , , AHMADLOO، NILOOFAR نويسنده , , MOSALAEI، AHMAD نويسنده , , MOHAMMADIANPANAH، MOHAMMAD نويسنده , , Ansari، Mansour نويسنده Shiraz University of Medical Sciences, Shiraz, Iran ,
Abstract :
The median overall survival in glioblastoma multiforme is usually less than one year.
Long-term survival is rare and is seen in only 3%-6% of GBM patients. The present
study reports the characteristics and treatment outcomes of six cases of glioblastoma
multiforme with long-term survival. A literature review is also presented.
Between 1990 and 2008, 217 glioblastoma multiforme patients have been treated
at our center of which six cases (four males) survived for three years or longer. The
mean age of the six cases was 25.7 years. All patients received postoperative radiotherapy
with a mean dose of 55 gray and four patients received nitrosourea-based chemotherapy.
Patientsʹ mean survival was 5.2 years. The results of this study and review of the literature
have indicated that long-term (more than three years) survival is exceptional and
mainly observed in younger patients with good performance status and following
complete surgical tumor resection.
