Author/Authors :
Movafagh، Abolfazl نويسنده Medical Genetics Department, Shaheed Beheshti University of Medical Sciences , , Hashemi، Mehrdad نويسنده , , Ghadiani، Mojtaba نويسنده Department of Internal Medicine/Oncology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Mirfakhraei، Reza نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Darvish، Hossein نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Zare Abdollahi، Davood نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Ghaedi، Hamid نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Safari، Shamsi نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , HaghNejad، Leyla نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Mosammami، Sara نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Safavi Naeini، Niloofar نويسنده Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Miri، Ramin نويسنده , , Rezaei-Tavirani، Mostafa نويسنده ,
Abstract :
Background: According to the literature, there are a number of chronic and acute
myeloid leukemias with unique, complex chromosome translocations. This study
aims to conduct a brief review of the incidence of complex chromosome translocations
in myeloid leukemia and reports a case of myeloid leukemia with complex chromosome
translocations.
Methods: We conducted a web-based search for all peer review articles published
on the subject of complex chromosome tranlsocations in chronic and acute myeloid
leukemia in MEDLINE, PubMed and Mitelman (http://cgapanci.nih.gov/
chromosomes/Mitelman) databases in addition to other pertinent web references. In
addition, we performed conventional cytogenetic studies of 24- to 72-h cultures on bone
marrow/peripheral blood cells obtained from the current case. Cells were finally
treated by the giemsa-trypsin-giemsa banding technique.
Results: The result of this case revealed an abnormal karyotype that had a novel
complex translocation which involved chromosomes 2, 5, 9, and 22. We performed
karyotyping after the initiation of chemotherapy. Karyotyping results showed a complex
karyotype 46,XX,t(9;22;2;5).
Conclusion: This study discusses a case of chronic myeloid leukemia with complex
chromosome translocations and may provide novel information regarding these
translocations in leukemias.
