Author/Authors :
Neshasteh-Riz، Ali نويسنده Radiology Department, College of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran , , Pashazadeh، Ali Mahmoud نويسنده The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran , , Rabie Mahdavi، Seyed نويسنده Faculty of Allied Medicine, Department of Radiation Sciences, Tehran University of Medical Sciences ,Tehran, Iran ,
Abstract :
Objective: To assess relative biological effectiveness (RBE) of
I radiation relative to
Co
gamma rays in glioblastoma spheroid cells.
Materials and Methods: In this experimental study, glioblastoma spheroid cells were
exposed to
131
I radiation and
Co gamma rays. Radiation induced DNA damage was
evaluated by alkaline comet assay. Samples of spheroid cells were treated by radiation
from
131
60
I for four different periods of time to find the dose-response equation. Spheroid
cells were also exposed by 200 cGy of
Co gamma rays as reference radiation to induce
DNA damage as endpoint.
Results: Resulted RBE of
131
60
I radiation relative to
Co gamma rays in 100 µm giloblastoma
spheroid cells was equal to 1.16.
Conclusion: The finding of this study suggests that
60
I photons and electrons can be more
effective than
60
131
Co gamma rays to produce DNA damage in glioblastoma spheroid cells.
