Title of article :
Antioxidative probiotic fermented goats milk decreases oxidative stress-mediated atherogenicity in human subjects
Author/Authors :
T.، Kullisaar نويسنده , , E.، Songisepp نويسنده , , M.، Mikelsaar نويسنده , , K.، Zilmer نويسنده , , T.، Vihalemm نويسنده , , M.، Zilmer نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
The increasing interest in a healthy diet is stimulating innovative development of novel scientific products in the food industry. The viable lactic acid bacteria in fermented milk products, such as yoghurt, have been associated with increased lactose tolerance, a well-balanced intestinal microflora, antimicrobial activity, stimulation of the immune system and antitumoural, anticholesterolaemic and antioxidative properties in human subjects. Recently, we have studied a human Lactobacillus spp. strain that possesses antioxidative activity. The aim of the present pilot study was to develop goatsʹ milk fermented with the human antioxidative lactobacilli strain, Lactobacillus fermentum ME-3, and to test the effect of the fermented probiotic goatsʹ milk on oxidative stress markers (including markers for atherosclerosis) in human blood and urine and on the gut microflora. Twenty-one healthy subjects were assigned to two treatment groups: goatsʹ milk group and fermented goatsʹ milk group (150 g/d) for a period of 21 d. Consumption of fermented goatsʹ milk improved anti-atherogenicity in healthy subjects: it prolonged resistance of the lipoprotein fraction to oxidation, lowered levels of peroxidized lipoproteins, oxidized LDL, 8isoprostanes and glutathione redox ratio, and enhanced total antioxidative activity. The consumption of fermented goatsʹ milk also altered both the prevalence and proportion of lactic acid bacteria species in the gut microflora of the subjects. We conclude that the goatsʹ milk fermented with our special antioxidative lactobacilli strain Lactobacillus fermentum ME-3 exhibits anti-atherogenic effects.
Keywords :
Fermented goatsmilk , Antioxidative activity , atherosclerosis , oxidized LDL , Glutathione redox ratio
Journal title :
BRITISH JOURNAL OF NUTRITION
Journal title :
BRITISH JOURNAL OF NUTRITION