Structure of the plaice glutathione S-transferase A gene

A clone coding for at least part of the plaice (Pleuronectes platessa) glutathione S-transferase A (GST A) gene and its upstream putative regulatory region was isolated from a plaice genomic DNA library. DNA sequence analysis characterised the first exon of this gene and indicated a number of potential upstream regulatory elements. Primer extension of plaice RNA established a transcriptional start site and these results are discussed with reference to mammmalian GST genes and their regulatory regions.