Cardio-Renal Profiling with hs-CRP and its Implications as a Diagnostic Tool in Chronic Kidney Disease Patients.

The prevalence of Chronic Kidney Disease-CKD is surprisingly high in Pakistani population, but unfortunately not unexpected, since incidence of hypertension and diabetes in our population is one of the highest in the world. CKD is defined as impaired glomerular filtration rate (GFR) or elevated albumin excretion in the urine, and has been recognized as an important risk factor contributing to cardiovascular disease and death. The most common risk factors for CKD includes; diabetes mellitus, hypertension, dyslipidemia and most important older age, but the clinical implications still remain uncertain in elderly persons suffering from CKD. The present study aims to evaluate the cardio-renal profile with hs-CRP in the patients with chronic kidney disease as compared to the healthy controls. Analysis of lipid profile (Cholesterol, Total Lipid, HDL-C, LDL-C, and Triglycerides), renal profile (Urea, Creatinine, BUN and Uric acid), Electrolytes (Sodium, Potassium, Chloride and Bicarbonate) and hs-CRP were carried out in CKD patients (n=50) as compared to the healthy individual (n=50) by using Automated and standardized kit methods. The present study may suggest that combined screening by cardio-renal profiling with hs-CRP could improve global risk prediction in CKD patients, who would otherwise not be identified for primary prevention by lipid assessment alone. This study also adds prognostic information and is helpful to elucidate new therapeutic strategies for the secondary prevention of CVD particularly in case chronic kidney disease or end stage renal failure.