Author/Authors :
Farhangniya، Mansoureh نويسنده Department of Genetics at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , , Dortaj Rabori، Eshagh نويسنده Department of Epidemiology and Statistic, Kerman University of Medical Science, Kerman, Iran , , Mozafari Kermani، Ramin نويسنده , , Haghdoost، Ali Akbar نويسنده Modeling Research Center, Kerman University of Medical Science, Kerman, Iran , , Bahrampour، Abbas نويسنده Professor of biostatistics, Department of biostatistics and Epidemiology, Kerman University of Medical Sciences, Kerman, Iran , , Bagheri، Pezhman نويسنده Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, IRAN , , Lancaster، Paul A. L. نويسنده Menzies Centre for Health Policy, School of Public Health, University of Sydney,Sydney, NSW Australia , , Ashrafi، Mahnaz نويسنده , , Vosough Taqi Dizaj، Ahmad نويسنده Department of Reproductive Imaging, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , , Gourabi، Hamid نويسنده , , Shahzadeh Fazeli، Abolhassan نويسنده Department of Genetics at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran ,
Abstract :
Background: In many countries, 1 to 3% of newborn infants are conceived by assisted reproductive
techniques (ART).
Despite the success of ART,
there is concern about the risk of congenital
malformations
among these infants. We
report our experience to determine whether use of ART
is
associated with an increase in major congenital malformations or adverse pregnancy outcomes.
Materials and Methods: Historical cohort study of major congenital malformations (MCM)
was performed in 978 births from January 2008 to December 2010. The data for this analysis
were derived from a Tehran’s ART linked data file by simple sampling method. In our study, the
risk of congenital malformations was compared in 326 ART infants and 652 naturally conceived
(NC) infants. We also performed multiple logistic regression analyses to calculate the odds ratio
(OR) and 95% confidence intervals (CI) for the independent association of ART on each outcome.
Results: We found 56 infants with major congenital malformations, these included 29 NC infants
(4.4%) and 27 ART
infants (8.3%). In comparison with NC infants, ART
infants had a significant
1.94-fold
increased
risk
of
MCM.After
adjustment
for
maternal
age,
infant’s
sex
stillbirth,
abortion and type of delivery,
we found a relatively small difference
in risk (OR=2.04). In
this
study the majority (94.3%) of all infants were normal but 5.7% of infants had at least one
MCM.
The
prevalence rate for the intracytoplasmic
sperm injection (ICSI) was
6.5% for the In
vitro
fertilisation (IVF) group was 15.9% or 2.73-fold higher than ICSI group (P=0.018). Also
we
ignore the possible role of genotype and other unknown factors in causing more malforma-
tions in ART infants.
Conclusion: Other studies have shown a slightly increased risk of major congenital mal-
formations in pregnancies resulting from ART. Likewise, this study reports a greater risk of
MCMs in ART infants than in naturally conceived infants. We also found evidence of a differ-
ence in risk of MCMs between IVF and ICSI. Musculoskeletal and urogenital malformations
were the most reported MCMs in ART infants according to organs and systems classification.
