A model for bilayer membrane electroporation based on resultant electromechanical stress

Reconsideration of the effect of an electrical field applied across a phospholipid bilayer membrane shows that, in addition to a compressive stress normal to the membrane plane, transverse traction stresses are generated in the lateral plane of the membrane. In the fields usually employed for electroporation these transverse stresses are likely to be sufficient to reduce the membrane tension considerably, causing electroporation and rupture. This mode of field-induced change in the membrane provides a natural model for the various forms of electroporation.