Author/Authors :
Sajedianfard ، J. نويسنده Department of Physiology, School of Veterinary Medicine, Shiraz University, P.O. Box 1731, Shiraz 71345, Iran. , , Rahdar ، M. نويسنده Department of Physiology, School of Veterinary Medicine, Shiraz University, P.O. Box 1731, Shiraz 71345, Iran. , , Nazifi ، S. نويسنده Department of Clinical Pathology, School of Veterinary Medicine, Shiraz University, P.O. Box 1731, Shiraz 71345, Iran. , , Farsani ، F. A. نويسنده Department of Physiology, School of Veterinary Medicine, Shiraz University, P.O. Box 1731, Shiraz 71345, Iran. ,
Abstract :
Ventromedial hypothalamic nucleus (VMH) is one of the brain regions responsible for regulating
gastrointestinal activities and lipid metabolism. Hepatic enzymes and serum lipids are controlled by the central
nervous system and VMH is involved in the regulation of lipid metabolism. In the present study we sought to
establish the role of serotonin to regulation of bile secretion, serum lipids level and hepatic enzymes in the rat.
Rats were cannulated in the VMH for the administration of serotonin. After 1 week the common bile duct was
cannulated and bile samples were collected after the administration of 5-HT, and biochemical analyses occurred
on blood samples. Centrally applied 5-HT increased bile secretion at all studied periods and also decreased
LDL-cholesterol (LDL-c) level. Present findings show that 5-HT participates in the central regulation of bile
secretion in the rat, and VMH can be a special site for regulation of bile secretion and lipid levels.
