Author/Authors :
Mousavi، Seyed Ali-Javad نويسنده Clinic of Obesity, Rasoule-Akram Hospital , Tehran University of Medical Sciences , , Kouchari، Mohammad- Reza نويسنده Research Center of Respiratory Diseases, Rasoule-Akram Hospital, Tehran University of Medical Sciences , , Samdani-Fard، Seyed Hossein نويسنده Tehran University of Medical Sciences, Tehran-Iran. , , Nasihati Gilvaee، Zahra نويسنده Tehran University of Medical Sciences, Tehran-Iran , , Arabi، Mohsen نويسنده Tehran University of Medical Sciences, Tehran-Iran ,
Abstract :
Background: This cross-sectional study aimed to investigate the relationship
between the levels of serum testosterone and the severity of chronic obstructive
pulmonary disease (COPD).
Materials and Methods: Using GOLD criteria, 140 male patients with COPD
were categorized into mild, moderate, severe and very severe COPD groups of
35 each. Then, serum levels of testosterone, prolactin and LH of patients were
compared and the data were analyzed using SPSS version 18 software.
Results: Average age of patients was 67.4±10.1 years (range 41 to 90 years). The
prevalence of the secondary hypogonadism was 58.6%. It was shown that the
level of serum testosterone was directly correlated with the severity of COPD
(P= 0.04).
Conclusion: This study found that the prevalence of the secondary
hypogonadism in COPD patients was high. The forced expiratory volume in 1
second (FEV1) was correlated with the level of serum testosterone. Further
investigations are required to better evaluate the pathology and treatment of
secondary hypogonadism in COPD patients.
