Author/Authors :
Marjani، Majid نويسنده , , Tabarsi، Payam نويسنده , , Baghaei، Parvaneh نويسنده , , Mahmoodi، Roya نويسنده Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Scienc , , Chitsaz، Ehsan نويسنده Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Scienc , , Rezaei، Elham نويسنده , , Shamaei، Masoud نويسنده , , Kazempour Dizaji، Mehdi نويسنده Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Scienc , , Valioallahpour Amiri، Majid نويسنده Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Scienc , , Mansouri، Seyed-Davood نويسنده , , Masjedi، Mohammad-Reza نويسنده ,
Abstract :
Background: Considering the rising trend of tuberculosis (TB) and cigarette smoking, an evaluation of the clinical
manifestations and drug resistance patterns in TB patients with regard to smoking status seemed beneficial.
Materials and Methods: Clinical manifestations and drug resistance patterns were studied in 872 new pulmonary TB
patients classified as non-smokers, ever-smokers, and passive smokers during 3 years at the National Research Institute of
Tuberculosis and Lung Disease. Both univariate and multivariate analyses were performed.
Results: Ever-smokers were mostly male (p < 0.001), Iranian (p < 0.001), and drug and alcohol users (p < 0.001). They were
found to have a longer patient delay (15.9 versus 8.7 and 6.3 days, p=0.008), shorter diagnostic delay (106.8 versus 132.6
and 156 days, p=0.01), greater weight loss (p=0.01), and higher sputum expectoration (p < 0.001). Notably, the degree of
smear positivity was associated with smoking (p < 0.001) in both univariate and multivariate analyses. No statistical
significance was found for the aforementioned factors among non-smokers and passive smokers.
Conclusion: Some of the clinical manifestations of TB are significantly different with regard to the patientsʹ smoking status.
The degree of sputum smear positivity for acid fast bacilli was higher and patient delay was longer in ever-smoker patients.
